Matrixyl
A cosmetic peptide used in anti-aging creams to support collagen. Small trials show modest wrinkle improvement.
- Evidence
- Limited human research
- Half-life
- Topical
- Sources
- 2 cited
Is matrixyl FDA-approved?
Cosmetic ingredient. Not an FDA-approved drug.
Overview
Matrixyl is the collagen fragment KTTKS with a fatty tail that helps it get into the skin. In a 12-week split-face trial in 93 women, the cream reduced fine lines and wrinkles compared with the same moisturizer without it.
How it works
KTTKS is a piece of collagen that, in lab studies, signals skin cells to make more collagen and other support proteins.
How long does matrixyl stay in the body?
Not applicable for topical use.
What it's studied for
- Fine lines and wrinkles
- Skin collagen
Related: Argireline, Vitamin B12, AHK-Cu, MIC (Lipotropic Injection).
Sources
The studies and prescribing labels this page is written from.
- Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin. Int J Cosmet Sci, 2005 PubMed
- Double-blind, randomized trial of acetylhexapeptide-3 cream and palmitoyl pentapeptide-4 cream for crow's feet. J Clin Aesthet Dermatol, 2023 PubMed
