FDA status of 78 peptides and GLP-1 medicines
In short
Of the 78 compounds in the PepBloom library, 22 are FDA-approved and 56 are not. Each row below says what the FDA has approved and when, as written on the compound's page, which cites its studies and drug labels. This page reports status only. It isn't advice to use any of them.
To check a medicine yourself, search FDA's Drugs@FDA database, or the Purple Book for biologics such as hCG and growth hormone.
FDA-approved (22)
| Compound | FDA status | Source |
|---|---|---|
| Semaglutide (Ozempic, Wegovy) | FDA-approved as Ozempic (2017), Rybelsus (2019) and Wegovy (2021). Wegovy was also approved for lowering heart attack and stroke risk in 2024. Compounded copies aren't FDA-approved. | DailyMed |
| Oral semaglutide (Rybelsus, Wegovy pill) | FDA-approved as Rybelsus (2019, type 2 diabetes) and as the Wegovy pill (December 2025, weight management and heart risk). The labels say: take it in the morning on an empty stomach with up to 4 oz of water, then wait at least 30 minutes before eating, drinking or taking other pills. | DailyMed |
| Tirzepatide (Mounjaro, Zepbound) | FDA-approved as Mounjaro (2022, type 2 diabetes) and Zepbound (2023, weight management; 2024, sleep apnea with obesity). Compounded copies aren't FDA-approved. | DailyMed |
| Liraglutide (Victoza, Saxenda) | FDA-approved as Victoza (2010, type 2 diabetes) and Saxenda (2014, weight management; teens 12+ since 2020). | DailyMed |
| Dulaglutide (Trulicity) | FDA-approved for type 2 diabetes since 2014. | DailyMed |
| Exenatide (Byetta, Bydureon) | FDA-approved for type 2 diabetes (Byetta 2005, Bydureon 2012). | DailyMed |
| Lixisenatide (Adlyxin) | FDA-approved in 2016 as Adlyxin. The stand-alone US product has since been discontinued; it's still sold combined with insulin glargine as Soliqua. | PubMed |
| Orforglipron (Foundayo) | FDA-approved as Foundayo on April 1, 2026 for chronic weight management in adults. Taken once a day, with or without food: the label sets no wait before eating. | DailyMed |
| Pramlintide (Symlin) | FDA-approved since 2005. | DailyMed |
| Setmelanotide (Imcivree) | FDA-approved (2020 for POMC, PCSK1 and LEPR deficiency; 2022 for Bardet-Biedl syndrome). | DailyMed |
| HCG (Novarel, Pregnyl) | FDA-approved prescription drug, regulated as a biologic since 2020, which ended routine compounding. | DailyMed |
| hMG (Menotropins, Menopur) | FDA-approved (Menopur) for fertility treatment. | DailyMed |
| Triptorelin (Trelstar, Triptodur) | FDA-approved as Trelstar (prostate cancer) and Triptodur (precocious puberty). | DailyMed |
| Oxytocin (Pitocin) | FDA-approved as an injection for labor. Nasal forms aren't FDA-approved in the US. | DailyMed |
| Teriparatide (Forteo) | FDA-approved since 2002. | DailyMed |
| PT-141 (Bremelanotide, Vyleesi) | FDA-approved in 2019 for HSDD in premenopausal women. | DailyMed |
| Melanotan I (Afamelanotide, Scenesse) | FDA-approved (2019) as Scenesse for EPP. Unregulated "Melanotan 1" sold online isn't the approved product. | DailyMed |
| HGH (Somatropin, Genotropin, Norditropin) | FDA-approved prescription drug. | DailyMed |
| Tesamorelin (Egrifta) | FDA-approved since 2010 for excess belly fat in HIV lipodystrophy. | DailyMed |
| Mecasermin (IGF-1, Increlex) | FDA-approved since 2005. | PubMed |
| SS-31 (Elamipretide, Forzinity) | FDA accelerated approval (Forzinity, 2025) to improve muscle strength in Barth syndrome. Other uses are investigational. | DailyMed |
| Vitamin B12 | FDA-approved as a prescription injection; pills are sold as supplements. | PubMed |
Not FDA-approved (56)
Products sold online as "research chemicals" aren't checked for purity, sterility or dose. Investigational means it is still in clinical trials.
| Compound | FDA status | Evidence |
|---|---|---|
| Retatrutide | Investigational. Not FDA-approved. | Ongoing clinical research |
| Cagrilintide | Investigational. Not FDA-approved. | Ongoing clinical research |
| CagriSema | Investigational. Not FDA-approved. | Ongoing clinical research |
| Survodutide | Investigational. Not FDA-approved. | Ongoing clinical research |
| Mazdutide | Approved in China (2025). Not FDA-approved. | Ongoing clinical research |
| Amycretin | Investigational. Not FDA-approved. | Ongoing clinical research |
| Maridebart Cafraglutide | Investigational. Not FDA-approved. | Ongoing clinical research |
| Petrelintide | Investigational. Not FDA-approved. | Ongoing clinical research |
| Eloralintide | Investigational. Not FDA-approved. | Ongoing clinical research |
| Pemvidutide | Investigational. Not FDA-approved. | Ongoing clinical research |
| Bimagrumab | Investigational. Not FDA-approved. | Ongoing clinical research |
| AOD-9604 | Not approved by the FDA. | Limited human research |
| HGH Fragment 176-191 | Not approved by the FDA. | Primarily preclinical research |
| 5-Amino-1MQ | Not approved by the FDA. | Primarily preclinical research |
| MOTS-c | Not approved by the FDA. | Primarily preclinical research |
| SLU-PP-332 | Not approved by the FDA. | Primarily preclinical research |
| Adipotide | Not approved by the FDA. | Primarily preclinical research |
| Kisspeptin-10 | Not approved by the FDA. | Limited human research |
| Gonadorelin | No branded product is currently marketed in the US. It's available through compounding pharmacies, and compounded versions aren't FDA-approved. | Limited human research |
| Sermorelin | The branded product is discontinued; compounded versions aren't FDA-approved. | Limited human research |
| Ipamorelin | Not approved by the FDA. | Limited human research |
| CJC-1295 | Not approved by the FDA. | Limited human research |
| Mod GRF 1-29 | Not approved by the FDA. | Primarily preclinical research |
| GHRP-2 | Not FDA-approved. | Limited human research |
| GHRP-6 | Not approved by the FDA. | Limited human research |
| Hexarelin | Not approved by the FDA. | Limited human research |
| MK-677 (Ibutamoren) | Not FDA-approved. | Limited human research |
| IGF-1 LR3 | Not approved by the FDA. | Primarily preclinical research |
| MGF (Mechano Growth Factor) | Not approved by the FDA. | Primarily preclinical research |
| Follistatin 344 | Not approved by the FDA. | Primarily preclinical research |
| BPC-157 | Not approved by the FDA. | Primarily preclinical research |
| TB-500 | Not approved by the FDA. | Primarily preclinical research |
| ARA-290 (Cibinetide) | Investigational. Not FDA-approved. | Limited human research |
| Semax | Approved in Russia. Not approved by the FDA. | Limited human research |
| Selank | Approved in Russia. Not approved by the FDA. | Limited human research |
| Cerebrolysin | Approved in many countries outside the US. Not FDA-approved. | Ongoing clinical research |
| Dihexa | Not approved by the FDA. | Primarily preclinical research |
| Pinealon | Not approved by the FDA. | Primarily preclinical research |
| Epitalon | Not approved by the FDA. | Primarily preclinical research |
| Humanin | Not approved by the FDA. | Primarily preclinical research |
| FOXO4-DRI | Not approved by the FDA. | Primarily preclinical research |
| Thymosin Alpha-1 | Approved in many countries outside the US. Not FDA-approved. | Ongoing clinical research |
| KPV | Not approved by the FDA. | Primarily preclinical research |
| LL-37 | Not approved by the FDA. | Limited human research |
| VIP (Vasoactive Intestinal Peptide) | Not FDA-approved. | Limited human research |
| Thymalin | Approved in Russia. Not approved by the FDA. | Limited human research |
| Larazotide | Investigational. Not FDA-approved. | Limited human research |
| DSIP | Not approved by the FDA. | Limited human research |
| Melanotan II | Not approved anywhere. Several countries' regulators have issued warnings about it. | Limited human research |
| NAD+ | Not an FDA-approved drug. Oral precursors are sold as supplements. | Limited human research |
| GHK-Cu | Sold in cosmetics. Injectable forms aren't FDA-approved. | Limited human research |
| AHK-Cu | Sold in cosmetics. Not an FDA-approved drug. | Primarily preclinical research |
| Argireline | Cosmetic ingredient. Not an FDA-approved drug. | Limited human research |
| Matrixyl | Cosmetic ingredient. Not an FDA-approved drug. | Limited human research |
| MIC (Lipotropic Injection) | Made by compounding pharmacies. Not an FDA-approved drug. | Limited human research |
| Glutathione | Sold as a supplement; injectable forms come from compounding pharmacies. Not an FDA-approved drug. | Limited human research |
